Latest Publications
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Blocking Mitochondrial Zn2+ Accumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury
The Journal of Neuroscience. 2022 Jun 29; 42 (26) 5281-5292. Medvedeva Y, Yin H, Bazrafkan A, Yeromin A, Ji S, Weiss-Hung E, Sharman E, Avilez A, Maki N, Rafi M, Tian G, Akbari Y, Weiss J. View here: PubMed | Journal Access Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome
Neurocritical Care. 2022 Jun 21; ePub ahead of print. Han S, Contreras M, Bazrafkan A, Rafi M, Dara SM, Orujyan A, Panossian A, Crouzet C, Lopour B, Choi B, Wilson R, Akbari Y. View here: PubMed | Journal Access Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model
Frontiers in Neuroscience. 2021 Jan 12; 14:609670. Azadian M, Tian G, Bazrafkan A, Maki N, Rafi M, Chetty N, Desai M, Otarola I, Aguirre F, Zaher S, Khan A, Suri Y, Wang M, Lopour B, Steward O, Akbari Y. View here: PubMed | Journal Access Resuscitating the Globally Ischemic Brain: TTM and Beyond
Neurotherapeutics. 2020 Apr; 17(2): 539-562. Hosseini M, Wilson RH, Crouzet C, Amirhekmat A, Wei KS, Akbari Y. View here: PubMed | Journal Access Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results
Journal of Stroke and Cerebrovascular Diseases. 2020 Sep 16; 29(12): 105321. Ghoreishi A, Arsang-Jang S, Sabaa-Ayoun Z, Yassi N, Sylaja P N , Akbari Y, Divani A A, Biller J, Phan T, Steinwender S, Silver B, Zand R, Bin Basri H, Iqbal O M, Ranta A, Ruland S, Macri E, Ma H, Nguyen T N, Abootalebi S, Gupta A, Alet M, Lattanzi S, Desai M, Gagliardi R J, Girotra T, Inoue M, Yoshimoto T, Isaac C F, Mayer S A, Morovatdar N, Nilanont Y, Nobleza C O S, Saber H, Kamenova S, Kondybayeva A, Krupinski J, Siegler J E, Stranges S, Torbey M T, Yorio D, Zurrú M C, Rubinos C A, Shahripour R B, Borhani-Haghighi A, Di Napoli M, Azarpazhooh M R. View here: PubMed | Journal Access The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting
Neurocritical Care. 2020 Jun 23; 33(1-12). Neurocritical Care Society Curing Coma Campaign. View here: PubMed | Journal Access Which Spreading Depolarizations Are Deleterious To Brain Tissue?
Neurocritical Care. 2020 Feb; 32(1):317-322. Shuttleworth C W, Andrew R D, Akbari Y, Ayata C, Balu R, Brennan K C, Boutelle M, Carlson A P, Dreier J P, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell S L, Jones S C, Kirov S A, Lindquist B E, Maciel C B, Okonkwo D, Reinhart K M, Robertson R M, Rosenthal E S, Watanabe T, Hartings J A. View here: PubMed | Journal Access Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery
Journal of the American Heart Association. 2020 Jan 7; 9(1):e012691. Crouzet C, Wilson RH, Lee D, Bazrafkan A, Tromberg BJ, Akbari Y, Choi B. View here: PubMed | Journal Access High-speed quantitative optical imaging of absolute metabolism in the rat cortex
Preprint. Wilson RH, Crouzet C, Torabzadeh M, Bazrafkan A, Maki N, Tromberg BJ, Akbari Y, Choi B. View here: BioRxiv | Journal Access Cerebral perfusion and metabolism coupling during a critical time window provides rapid assessment of cardiac arrest severity and prognosis in a preclinical model
Preprint. Wilson RH, Crouzet C, Torabzadeh M, Bazrafkan A, Maki N, Alcocer J, Tromberg BJ, Choi B, Akbari Y. View here: BioRxiv | Journal Access Overnight caloric restriction prior to cardiac arrest and resuscitation leads to improved survival and neurological outcome in a rodent model
Preprint. Azadian M, Tian G, Bazrafkan A, Maki N, Rafi M, Desai M, Otarola I, Zaher S, Khan A, Suri Y, Wang M, Steward O, Akbari Y. View here: BioRxiv | Journal Access Spreading depolarization and repolarization during cardiac arrest as an ultra-early marker of neurological recovery in a preclinical model
Preprint. Wilson RH, Crouzet C, Lee DE, Donga DP, Patel AH, Bazrafkan A, Maki N, Rafi MA, Moslehyazdi M, Pham JH, Torabzadeh M, Hjelm BE, Tromberg BJ, Steward O, Lopour BA, Choi B, Akbari Y. View here: BioRxiv | Journal Access Rapid intra-mitochondrial Zn2+ accumulation in CA1 hippocampal pyramidal neurons after transient global ischemia: A possible contributor to mitochondrial disruption and cell death.
Journal of Neuropathology & Experimental Neurology. Epub ahead of print. Yin HZ, Wang H, Ji SG, Medvedeva YV, Tian G, Bazrafkan A, Maki N, Akbari Y, Weiss JH. View here: PubMed | Journal Access High-speed spatial frequency domain imaging (SFDI) of rat cortex detects dynamic optical and physiological properties following cardiac arrest and resuscitation.
Neurophotonics. 2017 Oct;4(4):045008. Wilson RH, Crouzet M, Bazrafkan A, Farahabadi MH, Jamasian B, Donga D, Alcocer J, Zaher SM, Choi B, Akbari Y, Tromberg BJ. View here: PubMed | Journal Acces Resistant hypertension after hypertensive intracerebral hemorrhage is associated with more medical interventions and longer hospital stays without affecting outcome.
Front Neurol. 2017 May 3;8:184. Hong D, Stradling D, Dastur CK, Akbari Y, Groysman L, Al-Khoury L, Chen J, Small SL, Yu W. View here: PubMed | Journal Access Recovery from coma post-cardiac arrest is dependent on the orexin pathway.
J Neurotrauma. 2017 Apr 27. Kang YJ, Tian G, Bazrafkan A, Farahabadi MH, Azadian M, Abbasi H, Shamaoun B, Steward O, Akbari Y. View here: PubMed | Journal Access Neural correlates of consciousness at near-electrocerebral silence in an asphyxial cardiac arrest model.
Brain Connect. 2017 Apr;7(3):172-181. Lee DE, Lee LG, Siu D, Bazrafkan AK, Farahabadi MH, Dinh TJ, Orellana J, Xiong W, Lopour BA, Akbari Y. View here: PubMed | Journal Access Cerebral blood flow is decoupled from blood pressure and linked to EEG bursting after resuscitation from cardiac arrest.
Biomed Opt Express. 2016 Oct 20;7(11):4660-4673. Crouzet C, Wilson RH, Bazrafkan A, Farahabadi MH, Lee D, Alcocer J, Tromberg BJ, Choi B, Akbari Y. View here: PubMed | Journal Access |
Band specific changes in thalamocortical synchrony in field potentials after cardiac arrest induced global hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2013:7112-5. Maybhate A, Chen C, Akbari Y, Sherman DL, Shen K, Jia X, Thakor NV. PubMed | Journal Access
A new generation of therapeutic hypothermia: using a warm syringe to cool. Crit Care Med. 2011 Nov;39 (11):25589. Akbari Y, Geocadin RG.
PubMed | Journal Access
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Gen Physiol. 2008 Aug;132(2):i1. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PubMed | Journal Access
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May;26(5):645-54. Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PubMed | Journal Access
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PubMed | Journal Access
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31;39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PubMed | Journal Access
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci USA. 2002 Apr 2;99(7):4697-702.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Müller U, De Strooper B, Golde TE, LaFerla FM. PubMed | Journal Access
Band specific changes in thalamocortical synchrony in field potentials after cardiac arrest induced global hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2013:7112-5. Maybhate A, Chen C, Akbari Y, Sherman DL, Shen K, Jia X, Thakor NV. PubMed | Journal Access
A new generation of therapeutic hypothermia: using a warm syringe to cool. Crit Care Med. 2011 Nov;39 (11):25589. Akbari Y, Geocadin RG.
PubMed | Journal Access
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Gen Physiol. 2008 Aug;132(2):i1. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PubMed | Journal Access
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May;26(5):645-54. Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PubMed | Journal Access
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PubMed | Journal Access
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31;39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PubMed | Journal Access
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci USA. 2002 Apr 2;99(7):4697-702.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Müller U, De Strooper B, Golde TE, LaFerla FM. PubMed | Journal Access