Molecular Mechanisms

We aim to uncover the molecular mechanisms of neurological recovery following cardiac arrest,  including  the role of the orexin pathway and energy stores (e.g. caloric restriction, mitochondrial Zn2+).

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Hemodynamic Mechanisms

We aim to study various hemodynamic mechanisms, such as   CBF, brain metabolism, and neurovascular coupling , during and after cardiac arrest and cardiopulmonary resuscitation.

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Changes in Consciousness

We aim to uncover changes in consciousness during cardiac arrest, including   alterations in brain connectivity using quantitative
​EEG analysis.

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Multidisciplinary Approach

​To pursue these three goals, we have incorporated multidisciplinary techniques in  the  lab to maximize our translational potential, this includes:

• In-vivo techniques (surgery, electrophysiology, CA+CPR, and behavioral experiments).
• In-vitro techniques (molecular biology, histology/immunohistochemistry, protein quantification).
• Computational signal processing of EEG/ECoG.
• Advanced optical techniques (in close collaboration with the Beckman Laser Institute) to monitor changes in cerebral blood flow and brain metabolism during hyperdynamic periods of CA+CPR.