We aim to uncover the molecular mechanisms of neurological recovery following cardiac arrest, including the role of the orexin pathway and energy stores (e.g. caloric restriction, mitochondrial Zn2+).
We aim to study various hemodynamic mechanisms, such as CBF, brain metabolism, and neurovascular coupling , during and after cardiac arrest and cardiopulmonary resuscitation.
Changes in Consciousness
We aim to uncover changes in consciousness during cardiac arrest, including alterations in brain connectivity using quantitative
To pursue these three goals, we have incorporated multidisciplinary techniques in the lab to maximize our translational potential, this includes:
- In-vivo techniques (surgery, electrophysiology, CA+CPR, and behavioral experiments).
- In-vitro techniques (molecular biology, histology/immunohistochemistry, protein quantification).
- Computational signal processing of EEG/ECoG.
- Advanced optical techniques (in close collaboration with the Beckman Laser Institute) to monitor changes in cerebral blood flow and brain metabolism during hyperdynamic periods of CA+CPR.